Cycloheximide solution 

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL.

microbial

0.2 μm filtered

100 mg/mL in DMSO

2-8°C

Kominek, L.A. Antimicrob. Agents Chemother. 7, 856, (1975) abstract

Smith, A.D., et al. Dictionary of Microbiology and Molecular Biology, (1997)

Lennette, E.H., et al. Manual of Clinical Microbiology 4th ed., Washington D.C. , (1985), 500

Mizel, S.B., and Mizel, D. J. Immunol. 126, 834, (1981) abstract

Clemens, M.J., et al. Oncogene 17, 2921, (1998) abstract

Fulda, S. Cancer Res. 60, 3947, (2000) abstract

Ma, Q., et al. J. Biol. Chem. 275, 12676, (2000) abstract

Lin, W.W., and Hsu, Y.W. Cell. Signal. 12, 457, (2000) abstract

UN 2810 6.1/PG 2

3

189 °F

87 °C