CD30/Fc Chimera human 

The biological activity is measured by its ability to neutralize recombinant human CD30 ligand on HDLM-2 cells, a Hodgkin's lymphoma cell line.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

CD30, a type I transmembrane glycoprotein, is a member of the TNF receptor family. CD30 has a crucial role in the pathophysiology of Hodgkin's disease and other CD30⁺ lymphomas. The ligand for CD30 is CD30 ligand (CD30L). CD30-CD30L interaction mediates cell proliferation, cell activation, cell differentiation, and cell death.

The extracellular domain of human CD30/Fc Chimera (amino acids 1-379) is fused to the C-terminal Fc domain of human IgG.

expressed in mouse NSO cells

>95% (SDS-PAGE)

lyophilized powder

calculated mol wt 66 kDa

mol wt 100-110 kDa by SDS-PAGE (reducing)

Endotoxin, tested

human ... TNFRSF8(943)

−20°C

Durkop, H., et al. Cell 68, 421, (1992)

Chiarle, R., et al. J. Immunol. 163, 194, (1999)

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