C5922
Sigma

Monoclonal Anti-CNPase antibody produced in mouse

clone 11-5B, ascites fluid

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MDL number

MFCD00164572

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Descriptions

Immunogen

human 2',3'-cyclic nucleotide-3'-phosphodiesterase (E.C.3.1.4.37, CNPase).

Specificity

The antibody reacts specifically with CNPase in oligodendrocytes and Schwann cells. Recognizes whole brain CNPase. Nerve cells, axons, and astroglial cells do not appear to be labeled. Using immunoblotting techniques, the antibody localizes both CNP1 and CNP2 bands of the enzyme.

Properties

antibody form

ascites fluid

clone

11-5B

contains

15 mM sodium azide

species reactivity

human, bovine, mouse, rat, rabbit, canine, sheep, pig

does not react with

guinea pig, chicken

application(s)

immunoblotting: 1:500 using fresh bovine brain extract

immunohistochemistry: suitable using brain sections

indirect ELISA: suitable

microarray: suitable

isotype

IgG1

Gene Information

mouse ... Cnp(12799)

rat ... Cnp1(25275)

human ... CNP(1267)

shipped in

dry ice

storage temp.

−20°C

References

Reference

Sprinkle, T.J, et al., Monoclonal antibody production to human and bovine 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNPase): high-specificity recognition in whole brain acetone powders and conservation of sequence between CNP1 and CNP2. Brain Res. Brain Res. 426, 349-357, (1987) abstract

Sprinkle, T.J., 2′,3′-cyclic nucleotide 3′-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system. Crit. Rev. Neurobiol. 4, 235-301, (1989) abstract

Safety

WGK Germany

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Related Categories

... Antibodies for Neurobiology > Antibodies to Neural Proteins

... Alphabetical Index > CB to CN

... Neural Stem Cell Tracking > Glial Markers

... Neural Stem Cell Tracking > Oligodendrocyte Markers

... Clone Index > 1