C5923
Sigma

(−)-Cotinine

~98%

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Synonym

(S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone

S(−)-1-Methyl-5-(3-pyridyl)-2-pyrrolidone

Molecular Formula

C₁₀H₁₂N₂O

Molecular Weight

176.22

CAS Number

486-56-6

Beilstein Registry Number

83099

MDL number

MFCD00077696

PubChem Substance ID

24278324

EG/EC Number

207-634-9

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Descriptions

Biochem/physiol Actions

Major metabolite of nicotine in humans.

Properties

assay

~98%

250 °C/150 mmHg(lit.)

40-42 °C(lit.)

Gene Information

human ... CYP1A2(1544), CYP2A6(1548)

mouse ... Cyp2a5(13087)

storage temp.

2-8°C

References

Reference

Ghosheh, et al., Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine. Drug Metab. Dispos. 27, 1448, (1999) abstract

Green, et al., An oral formulation of nicotine for release and absorption in the colon: its development and pharmacokinetics. Br. J. Clin. Pharmacol. 48, 485-493, (1999) abstract

Merck

Merck 13,2578

Beilstein

Beil. 24,IV,312

reference

Corp MSDS 1 (1), 920:C / FT-IR 2 (3), 3757:A / FT-NMR 1 (3), 294:C / RegBook 1 (2), 2525:L / Sigma FT-IR 1 (1), 584:A / Structure Index 1, 398:A:7 / Vapor Phase 3, 1537:C

Safety

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

26-36

WGK Germany

RTECS

GN1925500

Flash Point(F)

230 °F

Flash Point(C)