C7344
Sigma

Cyclic adenosine diphosphate-ribose

≥90% (HPLC), lyophilized powder

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Synonym

ADP-cyclo[N¹:1′′]-ribose

cADP-ribose

cADPR

Cyclic ADPR

Molecular Formula

C₁₅H₂₁N₅O₁₃P₂

Molecular Weight

541.30

CAS Number

119340-53-3

MDL number

MFCD00214262

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Descriptions

Biochem/physiol Actions

Mobilizes intracellular Ca²⁺; regulates Ca²⁺-induced Ca²⁺ release specifically blocked by ryanodine; second messenger for glucose-induced insulin release from endocrine pancreas and for abscisic acid-induced calcium release in plants.

Packaging

Package size based on nucleotide content.

Physical form

Lyophilized powder containing approx. 30% sodium phosphate buffer salts.

Properties

assay

≥90% (HPLC)

form

lyophilized powder

storage temp.

−20°C

References

Reference

Lee, H.C., et al., Structural determination of a cyclic metabolite of NAD⁺ with intracellular Ca²⁺-mobilizing activity. J. Biol. Chem. 264, 1608-1615, (1989) abstract

Wu, Y., et al., Abscisic acid signaling through cyclic ADP-ribose in plants. Science 278, 2126-2130, (1997) abstract

Takasawa, S., et al., Cyclic ADP-ribose in insulin secretion from pancreatic beta cells. Science 259, 370-373, (1993) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Related Categories

... Intracellular Calcium Signaling > Intracellular Calcium Regulators

Celltransmissions 19(2) (135kb)

MSDS

Certificate of Analysis

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