C7632
Sigma

Cantharidin

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Synonym

3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione

7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran

Cantharidine

Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione

Molecular Formula

C₁₀H₁₂O₄

Molecular Weight

196.20

CAS Number

56-25-7

MDL number

MFCD00134968

PubChem Substance ID

24278334

EG/EC Number

200-263-3

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Descriptions

Biochem/physiol Actions

Inhibitor of protein phosphatase 2A.

Properties

color

white

215-217 °C(lit.)

solubility

DMSO: soluble

ethanol: soluble

Gene Information

human ... PPP2CA(5515), PPP2CB(5516), PPP2CBP(5517), PPP2R1A(5518), PPP2R1B(5519), PPP2R2A(5520), PPP2R2B(5521), PPP2R2C(5522), PPP2R3A(5523), PPP2R5A(5525)

References

Reference

Knapp, et al., The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J. Pharmacol. Exp. Ther. 289, 1480-1486, (1999) abstract

Krieser, et al., Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-GDI, during apoptosis. Cell Death Differ. 6, 412-419, (1999) abstract

Baskin, T.I., and Wilson J.E., Inhibitors of protein kinases and phosphatases alter root morphology and disorganize cortical microtubules. Plant Physiol. 113, 493-502, (1997) abstract

Knapp, et al., Contractility and inhibition of protein phosphatases by cantharidin. Gen. Pharmacol. 31, 729-733, (1998) abstract

Merck

Merck 13,1757

Beilstein

Beil. 19,161

reference

FT-IR 2 (1), 1214:C / Structure Index 1, 130:D:1

Safety

Hazard Codes

T+

Risk Statements

28-36/37/38

Safety Statements

53-45

RIDADR

UN 2811 6.1/PG 1

WGK Germany

RTECS

RN8575000

Related Categories

... Kinase/Phosphatase Biology > Phosphatase Inhibitors

... Serine/Threonine Phosphatase Inhibitors > Protein Phosphatase 2 (PP2)

FT-IR Raman

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information