Caffeic acid phenethyl ester 

Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product.¹ Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB.² CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.^3,4 Caffeic acid phenethyl ester inhibits HIV-1 integrase,^5,6 and also inhibits proliferation of transformed cells.^7,8 It induces apoptosis in transformed fibroblasts,⁹ and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.⁷

≥97% (HPLC)

powder

protect from light

off-white

ethyl acetate: 50 mg/mL

DMSO: soluble

ethanol: soluble

human ... NFKB2(4791)

−20°C

1. Grunberger, D., et al., Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 44, 230-232, (1988) abstract

2. Natarajan, K., et al., Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. USA 93, 9090-9095, (1996) abstract

3. Sud'ina, G.F., et al., Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 329, 21-24, (1993) abstract

4. Mirzoeva, O.K., and Calder, P.C., The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot. Essent. Fatty Acids 55, 441-449, (1996) abstract

5. Fesen, M.R., et al., Inhibitors of human immunodeficiency virus integrase. Proc. Natl. Acad. Sci. USA 90, 2399-2403, (1993) abstract

6. Fesen, M.R., et al., Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem. Pharmacol. 48, 595-608, (1994) abstract

7. Zheng, Z.S., et al., Caffeic acid phenethyl ester inhibits proliferation of human keratinocytes and interferes with the EGF regulation of ornithine decarboxylase. Oncol. Res. 7, 445-452, (1995) abstract

8. Su, Z.Z., et al., Growth suppression and toxicity induced by caffeic acid phenethyl ester (CAPE) in type 5 adenovirus-transformed rat embryo cells correlate directly with transformation progression. Cancer Res. 54, 1865-1870, (1994) abstract

9. Su, Z.Z., et al., Apoptosis mediates the selective toxicity of caffeic acid phenethyl ester (CAPE) toward oncogene-transformed rat embryo fibroblast cells. Anticancer Res. 15, 1841-1848, (1995) abstract

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UD3334375