| C9728 Sigma |
Cerebral Signal Transduction |
General description
This book emphasizes the functional role of the various signaling pathways in memory, apoptosis and degeneration, depression, and drug dependence in both health and diseases states. With the ability to selectively remove, reduce or enhance specific components of the signaling pathways, the book highlights the varied signaling cascades, their crosstalk and possibilities for changes in gene expression underlying changes in brain function. It discusses the development of novel therapeutics targeting downstream events in the cascade of second, third and fourth messengers.
Table of Contents
Part I. Introduction. From First To Fourth Messengers in the Brain: An Overview,
Part II. Memory. Cellular and Molecular Mechanisms of Learning and Memory.
Signal Transduction Pathways in Well-Defined Models of Learning and Memory: Drosophila and Honeybee,
Protein Kinase C Signaling in Learning and Memory,
Part III. Neurodegeneration and Apoptosis. Neurotransmitter Receptor-G-Protein Mediated Signal Transduction in Alzheimer's Disease.
The NO Signaling Pathway in the Brain: Neural Injury,
Neurological Disorders, and Aggression,
Cellular Signaling Pathways in Neuronal Apoptosis: Role in Neurodegeneration and Alzheimer's Disease,
The Role of Second Messengers in Neurodegeneration.
Part IV. Depression. Molecular and Cellular Determinants of Stress and Antidepressant Treatment.
Long-Term Bidirectional Hormonal and Neuroplastic Responses to Stress: Implications For the Treatment of Depression,
Signal Transduction Abnormalities in Bipolar Affective Disorder,
Part V. Drug Dependence. Messengers in Opioid Dependence: Gene Disruption Studies,
The 5-HT1B Knockout Mouse: An Animal Model of Vulnerability to Drugs of Abuse,
Regulation of Dopamine Transporter By Phosphorylation and Impact on Cocaine Action.
Dopamine Transporter mRNA in Human Brain: Distribution and Regulatory Effects in Autopsy Studies of Cocaine Abusers,
Index.
Part II. Memory. Cellular and Molecular Mechanisms of Learning and Memory.
Signal Transduction Pathways in Well-Defined Models of Learning and Memory: Drosophila and Honeybee,
Protein Kinase C Signaling in Learning and Memory,
Part III. Neurodegeneration and Apoptosis. Neurotransmitter Receptor-G-Protein Mediated Signal Transduction in Alzheimer's Disease.
The NO Signaling Pathway in the Brain: Neural Injury,
Neurological Disorders, and Aggression,
Cellular Signaling Pathways in Neuronal Apoptosis: Role in Neurodegeneration and Alzheimer's Disease,
The Role of Second Messengers in Neurodegeneration.
Part IV. Depression. Molecular and Cellular Determinants of Stress and Antidepressant Treatment.
Long-Term Bidirectional Hormonal and Neuroplastic Responses to Stress: Implications For the Treatment of Depression,
Signal Transduction Abnormalities in Bipolar Affective Disorder,
Part V. Drug Dependence. Messengers in Opioid Dependence: Gene Disruption Studies,
The 5-HT1B Knockout Mouse: An Animal Model of Vulnerability to Drugs of Abuse,
Regulation of Dopamine Transporter By Phosphorylation and Impact on Cocaine Action.
Dopamine Transporter mRNA in Human Brain: Distribution and Regulatory Effects in Autopsy Studies of Cocaine Abusers,
Index.
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