C9847
Sigma

Cyclothiazide

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Synonym

6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Molecular Formula

C₁₄H₁₆ClN₃O₄S₂

Molecular Weight

389.88

CAS Number

2259-96-3

MDL number

MFCD00210192

PubChem Substance ID

24278350

EG/EC Number

218-859-7

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Descriptions

Biochem/physiol Actions

Blocks the rapid desensitization of the AMPA glutamate receptors and markedly prolongs the decay time of the evoked excitatory post-synaptic current.

Properties

Gene Information

human ... CA1(759), CA4(762), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

rat ... Gria1(50592)

storage temp.

2-8°C

References

Reference

Trussell, L.O., et al., Desensitization of AMPA receptors upon multiquantal neurotransmitter release. Neuron 10, 1185, (1993) abstract

Tran, et al., AMPA receptor kinetics limit retinal amacrine cell excitatory synaptic responses. Vis. Neurosci. 16, 835-842, (1999) abstract

Schmidhammer, et al., Synthesis and biological evaluation of 14-alkoxymorphinans. 2.(-)-N-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective μ opioid receptor antagonist. J. Med. Chem. 32, 418, (1989) abstract

Schmidhammer, et al., Synthesis and biological evaluation of 14-alkoxymorphinans. 3. Extensive study on cyprodime-related compounds. J. Med. Chem. 33, 1200, (1990) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

DK9610000