D027
Sigma

R(−)-Propylnorapomorphine hydrochloride

solid

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Synonym

R(−)-10,11-Dihydroxy-N-n-propylnoraporphine hydrochloride

R(−)-NPA hydrochloride

Molecular Formula

C₁₉H₂₁NO₂ · HCl

Molecular Weight

331.84

CAS Number

18426-20-5

MDL number

MFCD00069239

PubChem Substance ID

24277901

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Descriptions

Biochem/physiol Actions

Highly potent and selective D₂ dopamine receptor agonist.

Caution

Subject to rapid oxidation.

Properties

form

solid

optical activity

[α]22/D −70.3°, c = 0.17 in methanol(lit.)

color

off-white

solubility

0.1 M HCl: 5-10 mg/mL Solutions should be freshly prepared

methanol: 5-10 mg/mL Solutions should be freshly prepared

H₂O: dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. Solutions should be freshly prepared.moderately soluble

alcohol: Solutions should be freshly prepared.moderately soluble

aqueous base: insoluble

abs.

ε_max/273 nm, ethanol 17,400

Gene Information

human ... DRD2(1813)

storage temp.

2-8°C

References

Reference

Creese, et al., N-Propylnorapomorphine[³H]-: A novel agonist ligand for central dopamine receptors. Eur. J. Pharmacol. 56, 411, (1979) abstract

Kimmel, H.L., et al., Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. J. Pharmacol. Exp. Ther. 298, 129, (2001) abstract

Kula, et al., Effects of isomers of apomorphines on dopamine receptors in striatal and limbic tissue of rat brain. Life Sci. 37, 1051, (1985) abstract

Safety

WGK Germany

Related Categories

... Dopaminergics > Agonists

MSDS

Certificate of Analysis

Certificate of Origin

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