Analysis Note
Measured by its ability to bind Netrin-2.
Biochem/physiol Actions
Shown to be a receptor for netrins, and is believed to act as a tumor-suppressor gene by inducing apoptosis in the absence of netrins. May be a useful prognostic factor in several types of cancer.
Other Notes
Extracellular domain of the long isoform of mouse DCC (amino acids 1-1097) fused to the C-terminal histidine-tagged Fc region of human IgG1.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
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