D0540
Sigma

DNQX

~98%

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Synonym

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

Molecular Formula

C₈H₄N₄O₆

Molecular Weight

252.14

CAS Number

2379-57-9

MDL number

MFCD00069257

PubChem Substance ID

24277973

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Descriptions

Biochem/physiol Actions

A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

Properties

assay

~98%

Gene Information

human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)

mouse ... Gria1(14799)

rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)

References

Reference

Muller, et al., Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science 242, 1694, (1988) abstract

Collingridge, et al., Excitatory amino acid receptors in the vertibrate central nervous system. Pharmacol. Rev. 40, 143, (1989)

Alford, S., Grillner, S., CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 506, 297, (1990) abstract

Layer, R.T., et al., Effects fo the AMPA/kainate receptor antagonist DNQX in the nucleus accumbens on drug-induced conditioned place preference. Brain Res. 617, 267, (1993) abstract

Safety

WGK Germany

Related Categories

... Excitatory Amino Acids > AMPA/Kainate Antagonists

... Ligand-Gated Ion Channels > Ionotropic Glutamate Receptor Modulators

MSDS

Certificate of Analysis

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D0540 (Sigma)