(±)-DOI hydrochloride 

(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.

≥98% (HPLC)

solid

Home Office Schedule 1

white to off-white

H₂O: 10 mg/mL

ethanol: 2 mg/mL

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Gaggi, R., et al., Effect of the selective 5-HT receptor agonists 8-OHDPAT and DOI on behavior and brain biogenic amines of rats. Gen. Pharmacol. 28, 583-587, (1997) abstract

Marek, G.J., et al., LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT_2A receptors on interneurons in rat piriform cortex. J. Pharmacol. Exp. Ther. 278, 1373-1382, (1996) abstract

Ichikawa, J., et al., DOI, a 5-HT_2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum. Brain Res. 698, 204-208, (1995) abstract

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