D133
Sigma

6,7-Dichloroquinoxaline-2,3-dione

Synonym

6,7-Dichloro-2,3-quinoxalinedione

DCQX

Molecular Formula

C₈H₄Cl₂N₂O₂

Molecular Weight

231.04

CAS Number

25983-13-5

MDL number

MFCD00078575

PubChem Substance ID

24277975

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Descriptions

Biochem/physiol Actions

Antagonist at the NMDA glutamate receptor glycine site.

Properties

Gene Information

human ... GRIN1(2902)

rat ... Gria1(50592), Grin2a(24409)

References

Reference

Matsumoto, R.R., et al., Novel NMDA/glycine site antagonists attenuate cocaine-induced behavioral toxicity. Eur. J. Pharmacol. 338, 233-242, (1997) abstract

Ogita, K., and Yoneda, Y., 6,7-Dichloroquinoxaline-2,3-dione is a competitive antagonist specific to strychnine-insensitive [³H]glycine binding sites on the N-methyl-D-aspartate receptor complex. J. Neurochem. 54, 699-702, (1990) abstract

Safety

WGK Germany

Related Categories

... Ligand-Gated Ion Channels > Ionotropic Glutamate Receptor Modulators

... Excitatory Amino Acids > NMDA Antagonists

MSDS

Certificate of Analysis

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D133 (Sigma)