D1756
Sigma

Dexamethasone

≥98% (HPLC), powder

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Synonym

9α-Fluoro-16α-methylprednisolone

Prednisolone F

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione

Molecular Formula

C₂₂H₂₉FO₅

Molecular Weight

392.46

CAS Number

50-02-2

Beilstein Registry Number

2066651

MDL number

MFCD00064136

PubChem Substance ID

24893536

EG/EC Number

200-003-9

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Descriptions

Frequently Asked Questions

Live Chat and Frequently Asked Questions are available for this Product.

Reconstitution

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Properties

assay

≥98% (HPLC)

form

powder

color

off-white

262-264 °C(lit.)

solubility

ethanol: 1 mg/mL

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)

rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)

storage temp.

2-8°C

References

Reference

Riccardi, C., et al., Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes. Cell Death Differ. 6, 1182-1189, (1999)

Wershil, B.K., et al., Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms. Int. Arch. Allergy Immunol. 107, 323-324, (1995)

Llanos, S.L., and Roldan, A., Effect of dexamethasone on nitric oxide (NO) production by cultured astrocytes. Bio. Cell. 23, 29-35, (1999)

Merck

Merck 13,2960

reference

Aldrich MSDS 1, 556:D / Corp MSDS 1 (1), 1039:B / FT-NMR 1 (3), 585:C / RegBook 1 (2), 2863:L / Sax 6, 2493 / Sigma FT-IR 1 (1), 1233:A / Structure Index 1, 458:A:8

Safety

Hazard Codes

Risk Statements

Safety Statements

36/37

WGK Germany

RTECS

TU3980000