D1916
Sigma

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

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Synonym

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

5,6-Dichlorobenzimidazole riboside

DRB

Molecular Formula

C₁₂H₁₂Cl₂N₂O₄

Molecular Weight

319.14

CAS Number

53-85-0

Beilstein Registry Number

39123

MDL number

MFCD00036785

PubChem Substance ID

24278361

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Descriptions

Biochem/physiol Actions

Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.

Properties

Gene Information

human ... CSNK2A1(1457), CSNK2B(1460)

storage temp.

−20°C

References

Reference

Bradley J., and Sporns, O., BDNF-dependent enhancement of exocytosis in cultured cortical neurons requires translation but not transcription. Brain Res. 815, 140-149, (1999) abstract

Ljungman M., et al., Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene 18, 583-592, (1999) abstract

Primorac, D., et al., Premature termination codon in the Aggrecan gene of Nanomelia and its influence on mRNA transport and stability. Croat. Med. J. 40, 528-532, (1999) abstract

Poele R.H., et al., RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene 18, 5765-5772, (1999) abstract

Beilstein

Beil. 23,IV,1097

Safety

WGK Germany

RTECS

DD7310000

10-23

Related Categories

... Gene Regulation and Expression > DNA-RNA Transcription Regulators

... Antitumor Agents > DNA-RNA Transcription Regulators

... Protein Kinases and Phosphatases > Protein Kinase Inhibitors and Related Products

D1916 - Product Information Sheet (13kb)

MSDS

Specification Sheet

Certificate of Analysis

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