Biochanin A 

Biochanin A is an isoflavone phytoestrogen found in red clover (Trifolium pratense) that is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels.

210-213 °C(lit.)

Escande, A., et al., Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor α or β. Biochem. Pharmacol. 71, 1459-1469, (2006)

Torregrosa, G., et al., Pharmacological profile of phytoestrogens in cerebral vessels: in vitro study with rabbit basilar artery. Eur. J. Pharmacol. 482, 227-234, (2003)

Wang, H.P., et al., Mechanisms underlying biochanin A-induced relaxation of the aorta differ between normotensive and hypertensive rats. Clin. Exp. Pharmacol. Physiol. 33, 802-807, (2006)

Han, E.H., et al., Effect of biochanin A on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Arch. Pharm. Res. 29, 570-576, (2006)

Beil. 18,V,4,595

FT-IR 2 (2), 2509:A / FT-IR 1 (2), 95:D / FT-NMR 1 (2), 920:A / IR-Spectra (3), 906:B / IR-Spectra (2), 792:H / NMR-Reference 2 (2), 98:C / RegBook 1 (2), 1697:G / Sigma FT-IR 1 (2), 476:A / Structure Index 1, 270:B:1

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