D2521
Sigma

(+)-cis-Diltiazem hydrochloride

≥99% (HPLC)

1 of 1

Synonym

(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride

CRD-401

Molecular Formula

C₂₂H₂₆N₂O₄S · HCl

Molecular Weight

450.98

CAS Number

33286-22-5

Beilstein Registry Number

4228706

MDL number

MFCD00069252

PubChem Substance ID

24277849

EG/EC Number

251-443-3

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Descriptions

Biochem/physiol Actions

Blocks slow, or L-type Ca²⁺ channels; regulates Ca²⁺ release from intracellular stores in neutrophils; stimulates 1,4-dihydropyridine binding to Ca²⁺ channels; coronary vasodilator.

Properties

assay

≥99% (HPLC)

storage temp.

2-8°C

References

Reference

Gunthorpe, M.J., et al. J. Physiol. 519, 713, (1999) abstract

Dobrev, D., et al. Br. J. Pharmacol. 127, 576, (1999) abstract

Smirnov, S.V., and Aaronson, P.I. Eur. J. Pharmacol. 360, 81, (1998) abstract

Merck

Merck 13,3226

Safety

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

RTECS

DL0310000

8-10

Related Categories

... Calcium Channel Modulators > Inhibitors and Activators

... Xenobiotics and Drug Metabolism > Substrates

Calcium Channels (178 kb)

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information