D3688
Sigma

Anti-DR3, Extracellular Domain antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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Synonym

Anti-Apo-3

Anti-Death Receptor 3

Anti-LARD

Anti-TRAMP

Anti-Wsl-1

MDL number

MFCD01864346

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Descriptions

Immunogen

synthetic peptide corresponding to amino acids 59-77 of the extracellular domain of human DR3 precursor.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Properties

antibody form

IgG fraction of antiserum

form

buffered aqueous solution

mol wt

antigen mol wt 59 kDa

species reactivity

human

application(s)

immunoblotting: 0.5 μg/mL using human Jurkat cell extract

Gene Information

human ... TNFRSF25(8718)

shipped in

dry ice

storage temp.

−20°C

References

Reference

Chinnaiyan, A.M., et al., Signal transduction by DR3a death domain-containing receptor related to TNFR-1 and CD95. Science 274, 990-992, (1996) abstract

Screaton, G.R., et al., LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 94, 4615-4619, (1997) abstract

Kitson, J., et al., A death-domain-containing receptor that mediates apoptosis. Nature 384, 372-375, (1996) abstract

Marsters, S.A., et al., Identification of a ligand for the death-domain-containing receptor Apo3. Curr. Biol. 8, 525-528, (1988)

Safety

WGK Germany