D4000
Sigma

trans-Dehydroandrosterone

≥99%

zoom

1 of 1

Synonym

3β-Hydroxy-5-androsten-17-one

5-Androsten-3β-ol-17-one

Dehydroepiandrosterone

Dehydroisoandrosterone

DHEA

Prasterone

Molecular Formula

C₁₉H₂₈O₂

Molecular Weight

288.42

CAS Number

53-43-0

Beilstein Registry Number

2058110

MDL number

MFCD00003613

PubChem Substance ID

24278369

EG/EC Number

200-175-5

Expand/Collapse All

Descriptions

Biochem/physiol Actions

Negative modulator of GABA_A receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.

Properties

assay

≥99%

drug control

Home Office Schedule 4.2

149-151 °C(lit.)

Gene Information

rat ... Ar(24208)

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SERPINA6(866)

References

Reference

Ebeling, P., and Koivisto, V.A., Physiological importance of dehydroepiandrosterone. Lancet 343, 1479-1481, (1994) abstract

Nakata, T., et al., Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients. J. Steroid Biochem. Mol. Biol. 86, 455-460, (2003) abstract

Merck

Merck 13,7798

Beilstein

Beil. 8,IV,994

reference

Aldrich MSDS 1, 555:B / Corp MSDS 1 (1), 1023:B / FT-IR 2 (3), 4225:B / FT-IR 1 (2), 1050:D / FT-NMR 1 (3), 573:B / IR-Spectra (3), 1495:F / IR-Spectra (2), 1279:E / NMR-Reference 2 (2), 922:A / RegBook 1 (2), 2857:M / Sigma FT-IR 1 (1), 1227:B / Structure Index 1, 457:D:8

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

BV8396000