D5297
Sigma

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate

≥98%, powder

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Synonym

5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate

Prasterone sulfate sodium salt dihydrate

Sodium dehydroepiandrosterone sulfate

Molecular Formula

C₁₉H₂₇NaO₅S · 2H₂O

Molecular Weight

426.50

CAS Number

78590-17-7

PubChem Substance ID

24278373

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Descriptions

Biochem/physiol Actions

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate is a negative allosteric modulator of GABA_A receptors.

Properties

assay

≥98%

form

powder

drug control

Home Office Schedule 4.2

color

white to off-white

solubility

methanol: clear to hazy

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

References

Reference

Lapchak, P.A., et al., Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors. Stroke 31, 1953-1957, (2000)

Hansen, S.L., et al., Differential blockade of gamma-aminobutyric acid type A receptors by the neuroactive steroid dehydroepiandrosterone sulfate in posterior and intermediate pituitary. Mol. Pharmacol. 55, 489-496, (1999) abstract

Park-Chung, M., et al., Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites. Brain Res. 830, 72-87, (1999) abstract

Nilsson, K.R., et al., Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfatepregnenolone sulfateand (3alpha5beta)-3-hydroxypregnan-20-one sulfate. J. Med. Chem. 41, 2604-2613, (1998) abstract

Safety

WGK Germany

Related Categories

... Ligand-Gated Ion Channels > GABA and Glycine Receptor Modulators

... GABAergics > Others

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information