D5942
Sigma

DAPT

≥98% (HPLC), solid

zoom

1 of 1

Synonym

LY-374973

N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester

Molecular Formula

C₂₃H₂₆F₂N₂O₄

Molecular Weight

432.46

CAS Number

208255-80-5

MDL number

MFCD04974585

PubChem Substance ID

24893987

Expand/Collapse All

Descriptions

Frequently Asked Questions

Live Chat and Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

DAPT is a γ-secretase inhibitor.

Legal Information

Sold under license to US patent numbers 6, 211,235 and 6,191,166

Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~18 mg/mL

Gene Information

mouse ... Aph1a(226548), Aph1b(208117), Ncstn(59287), Notch1(18128), Notch2(18129), Notch3(18131), Notch4(18132), Psen1(19164), Psen2(19165), Psenen(66340)

rat ... Aph1a(365872), Aph1b(300802), Ncstn(289231), Notch1(25496), Notch2(29492), Notch3(56761), Notch4(406162), Psen1(29192), Psen2(81751), Psenen(292788)

human ... APH1A(51107), APH1B(83464), NCSTN(23385), NOTCH1(4851), NOTCH2(4853), NOTCH3(4854), NOTCH4(4855), PSEN1(5663), PSEN2(5664), PSENEN(55851)

storage temp.

2-8°C

References

Reference

Micchelli, C.A., et al., γ-Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 17, 79-81, (2003)

Lammich, S., et al., Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J. Biol. Chem. 277, 44754-44759, (2002)

Dovey, H.F., et al., Functional γ-secretase inhibitors reduce β-amyloid peptide levels in brain. J. Neurochem. 76, 173-181, (2001)

Safety

WGK Germany

Related Categories

... R to Z > gamma Secretase

MSDS

Certificate of Analysis

More Information

Related Categories

Printer Friendly View

Bulk Quote

Ask A Scientist

Last 5 Products Viewed

D5942 (Sigma)