D6908
Sigma

DL-erythro-Dihydrosphingosine

≥99%, synthetic

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Synonym

DL-erythro-1,3-Dihydroxy-2-aminooctadecane

DL-erythro-2-Amino-1,3-octadecanediol

DL-Sphinganine

Molecular Formula

C₁₈H₃₉NO₂

Molecular Weight

301.51

CAS Number

3102-56-5

Beilstein Registry Number

1724234

MDL number

MFCD00079141

PubChem Substance ID

24278382

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Descriptions

Biochem/physiol Actions

D-Isomer is the biosynthetic precursor of sphingosine; inhibits protein kinase C, phospholipase A₂, and phospholipase D.

Properties

biological source

synthetic

assay

≥99%

Gene Information

human ... PLD1(5337), PLD2(5338), PLD3(23646), PLD4(122618), PLD5(200150), PPP2CA(5515), PPP2CB(5516), PPP2CBP(5517), PPP2R1A(5518), PPP2R1B(5519), PPP2R2A(5520), PPP2R2B(5521), PPP2R2C(5522), PPP2R3A(5523), PRKCA(5578), PRKCB1(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584)

storage temp.

−20°C

References

Reference

Sakakura, et al., Selectivity of sphingosine-induced apoptosis Lack of activity of DL-erythyro-dihydrosphingosine. Biochem. Biophys. Res. Commun. 246, 827-30, (1998) abstract

Archibald, Structural studies of lipid fibers formed by sphingosine. Biochim. Biophys. Acta 1166, 154-162, (1993) abstract

Beilstein

Beil. 4,IV,1887

Safety

WGK Germany