D7693
Sigma

Dynasore monohydrate

≥98% (HPLC), solid

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Synonym

3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide monohydrate

Molecular Formula

C₁₈H₁₄N₂O₄ · H₂O

Molecular Weight

340.33

CAS Number

304448-55-3 (anhydrous)

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Descriptions

Biochem/physiol Actions

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Properties

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

off-white

solubility

DMSO: ≥10 mg/mL

H₂O: insoluble

storage temp.

−20°C

References

Reference

Thompson, H.M., and McNiven, M.A., Discovery of a new 'dynasore'. Nature Chem. Biol. 2, 355-356, (2006)

Macia, E., et al., Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell 10, 839-850, (2006) abstract

Nakoe, S.R., and Sever, S., Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation. Trends Cell Biol. 16, 607-609, (2006) abstract

Newton, A.J., et al., Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc. Natl. Acad. Sci. USA 103, 17955-17960, (2006) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

22-24/25-61

RIDADR

UN 3077 9/PG 3