E1528
Sigma

Estrogen Receptor-α human

≥80% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

MDL number

MFCD00676964

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Descriptions

Physical form

Solution in 50 mM Tris-HCl, pH 8.0, 500 mM KCl, 2 mM DTT, 1 mM EDTA, 1 mM orthovanadate, and 10% glycerol.

Biochem/physiol Actions

Hormone-inducible transcription factor capable of acting positively or negatively in regulating genes involved in tissue growth and differentiation. For use in signal transduction, steroid biochemistry, and endocrine disruptor research.

Properties

recombinant

expressed in baculovirus infected insect cells

assay

≥80% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

mol wt 66.4 kDa

packaging

vial of 750 (pmol per vial)

Gene Information

human ... ESR1(2099)

shipped in

dry ice

storage temp.

−70°C

References

Reference

Paech, K., Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277, 1508, (1997) abstract

Kuiper, G.G., Comparison of the ligand binding specificity and transcript tissue distribution of estrogen. Endocrinology 138, 863, (1997) abstract

Kuiper, G.G., Cloning of a novel receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. USA 93, 5925, (1996) abstract

Mosselman, S., ERβ: identification and characterization of a novel human estrogen receptor. FEBS Lett. 392, 49, (1996) abstract

Safety

WGK Germany