Epidermal Growth Factor Receptor human 

Affinity purified from human carcinoma A431 cells.

One unit will catalyze the incorporation of 1 pmol of phosphate from γ-³²P-ATP into poly (Glu,Tyr), 4:1 at 30 °C per min.

Lyophilized from a solution in 50 mM HEPES, pH 7.6, 150 mM NaCl, 0.05% Triton X-100, 1 mM dithiothreitol, and 10% trehalose.

EGF exerts its actions by binding to the EGF receptor (EGFR), a 170 kDa glycoprotein having EGF-activated protein tyrosine kinase activity. Even in the absence of EGF-like ligands, EGFR can participate in cellular responses elicited by several other stimuli. High levels of EGFR are expressed in approximately one third of human epithelial tumors, and in the cancers of the bladder, breast or lung that have poor clinical prognosis, hence the interest in targeting EGFR.

lyophilized powder

human ... EGFR(1956)

dry ice

−20°C

Panayotou, G., et al. Receptor Purification 1, 289, (1990)

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