Other Notes
Epoxide hydrolase functions to render epoxides less chemically reactive. Two forms of human hydrolase are involved in this process, microsomal epoxide hydrolase (mEH) and soluble epoxide hydrolase. mEH is an enzyme of the endoplasmic reticulum. Although typically expressed in the liver, it is also present at significant levels in other tissues such as the adrenal gland. The primary characteristics of mEH substrates include marked lipophilicity and a lack of any trans-substitutions on the oxirane ring.