E8399
Sigma

Eotaxin-3 human

>97% (SDS-PAGE), recombinant, expressed in Escherichia coli, lyophilized powder, cell culture tested

Synonym

CCL26

SCYA26

MDL number

MFCD01867165

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Descriptions

Analysis Note

The biological activity is measured by its ability to induce chemotaxis of rat Y3 cells stably expressing hCCR3.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.

Biochem/physiol Actions

Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. Mature recombinant human eotaxin-3 has a molecular mass of approximately 8.2 kDa and demonstrates chemotactic activity for eosinophils.

Properties

recombinant

expressed in Escherichia coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

total impurities

Endotoxin, tested

suitability

cell culture tested

Gene Information

human ... CCL26(10344)

storage temp.

−20°C

References

Reference

Kitaura, M., et al., Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274, 27975-27980, (1999) abstract

Shinkai, A., et al., A novel human CC chemokine eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells exhibits potent activity toward eosinophils. J. Immunol. 163, 1602-1610, (1999) abstract

Safety

WGK Germany