E8875
Sigma

β-Estradiol

≥98%

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1 of 1

Synonym

1,3,5-Estratriene-3,17β-diol

17β-Estradiol

3,17β-Dihydroxy-1,3,5(10)-estratriene

Dihydrofolliculin

Molecular Formula

C₁₈H₂₄O₂

Molecular Weight

272.38

CAS Number

50-28-2

Beilstein Registry Number

1914275

MDL number

MFCD00003693

PubChem Substance ID

24278426

EG/EC Number

200-023-8

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Descriptions

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Properties

assay

≥98%

176-180 °C(lit.)

References

Reference

Beato, M., Gene regulation by steroid hormones. Cell 56, 335-344, (1989)

Shao, W., and Brown, M., Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Breast Cancer Res. 6, 39-52, (2003)

Yue, W., et al., Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis. J. Steroid Biochem. Mol. Biol. 86, 477-486, (2003)

Merck

Merck 13,3738

Beilstein

Beil. 6,IV,6611

reference

Corp MSDS 1 (1), 1534:B / FT-IR 2 (3), 4237:B / FT-IR 1 (2), 1055:C / FT-NMR 1 (3), 589:B / RegBook 1 (2), 2865:K / Sax 6, 1298 / Sigma FT-IR 1 (1), 1243:D / Structure Index 1, 459:D:2

Safety

Hazard Codes

Risk Statements

Safety Statements

53-45

WGK Germany

RTECS

KG2975000

8-10