E9387
Sigma

Big Endothelin 38 human

≥95% (HPLC)

Amino Acid Sequence

Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser [Disulfide Bridges: 1-15; 3-11]

Molecular Formula

C₁₈₉H₂₈₂N₄₈O₅₆S₅

Molecular Weight

4282.87

CAS Number

120796-97-6

MDL number

MFCD00081408

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Descriptions

Biochem/physiol Actions

Precursor of endothelin 1; vasoconstrictor activity appears to be due to its conversion to endothelin 1 by endothelin converting enzyme in the tissue.

Properties

assay

≥95% (HPLC)

Gene Information

human ... EDN1(1906)

storage temp.

−20°C

References

Reference

Burkhardt, M., Receptor- and non-receptor-mediated clearance of big-endothelin and endothelin-1: differential effects of acute and chronic ET_A receptor blockade. J. Hypertens. 18, 273, (2000) abstract

Yap, E.Y., et al., Contraction to big endothelin-1 big endothelin-2 and big endothelin-3 and endothelin-converting enzyme inhibition in human isolated bronchi. Br. J. Pharmacol. 129, 170-176, (2000) abstract

Schilling, L., et al., Characterization of the contractile and relaxant action of the endothelin-1 precursor, big endothelin-1, in the isolated rat basilar artery. Peptides 21, 91-99, (2000) abstract

Safety

WGK Germany

Related Categories

... Cell Signaling Enzymes > Chymase and Related Products

... Endothelins > Precursors

MSDS

Specification Sheet

Certificate of Analysis

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E9387 (Sigma)