E9777
Sigma

EphB6/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder

Synonym

Mep

MDL number

MFCD01867529

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Descriptions

Analysis Note

The biological activity is measured by its ability to bind recombinant mouse ephrin-B2/Fc in an ELISA assay.

Biochem/physiol Actions

Member of Eph receptor tyrosine kinase family shown to bind ephrin-B1 and ephrin-B2; involved in pattern formation and morphogenesis.

Other Notes

Extracellular domain of mouse EphB6 (amino acids 1-587) fused to the C-terminal 6X histidine-tagged Fc region of human IgG1 via a polypeptide linker.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Properties

recombinant

expressed in mouse NSO cells

assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

monomer calculated mol wt 87.3 kDa

mol wt ~100 kDa by SDS-PAGE (reducing)

total impurities

Endotoxin, tested

Gene Information

mouse ... Ephb6(13848)

storage temp.

−20°C

References

Reference

Flanagan, J.G., Vanderhaegen, P., The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci. 21, 309, (1998)

Pasquale, E.B., The Eph family of receptors. Curr. Opin. Cell Biol. 9, 608, (1997)

Gurniak, C.B., Berg, L.J. Oncogene 13, 777, (1996)

Safety

WGK Germany

Related Categories

... Receptor Tyrosine Kinases > Eph

... Ephrin and Eph Receptors > Eph Receptor

... Protein Kinases and Phosphatases > Receptor Protein Tyrosine Kinases

... Cell Signaling Enzymes > Signal Transduction

... Angiogenesis > Vessel Growth Regulators

E9777 - Datasheet (55kb)

MSDS

Certificate of Analysis

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E9777 (Sigma)