F1175
Sigma

Follistatin 300 human

≥90% (SDS-PAGE), recombinant, expressed in Sf21 cells, lyophilized powder, cell culture tested

Synonym

FS 300

MDL number

MFCD02098540

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Descriptions

Analysis Note

The biological activity is measured by its ability to neutralize activin-induced bioactivity on K562 cells (erythroid differentiation).

Biochem/physiol Actions

High-affinity activin-binding protein that can act as an activin antagonist.

Physical form

Lyophilized from a solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.

Properties

recombinant

expressed in Sf21 cells

assay

≥90% (SDS-PAGE)

form

lyophilized powder

total impurities

Endotoxin, tested

suitability

cell culture tested

Gene Information

human ... FST(10468)

storage temp.

−20°C

References

Reference

Guo, Q., et al., Overexpression of mouse follistatin causes reproductive defects in transgenic mice. Mol. Endocrinol. 12, 96-106, (1998) abstract

Hasimoto, O., et al., A novel role of follistatin an activin-binding protein in the inhibition of activin action in rat pituitary cells. J. Biol. Chem. 272, 13835-13842, (1997) abstract

Lemura, S., et al., Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc. Natl. Acad. Sci. USA 95, 9337, (1998) abstract

Safety

Hazard Codes

Risk Statements

20/21/22-36

Safety Statements