Ferritin from human spleen 

A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.

sterile-filtered

Type V

vial of 2 μg

10 μg/mL in 0.15 M NaCl, 10 mM Tris, pH 8.0, containing 0.1% sodium azide

human ... FTH1(2495), FTL(2512)

2-8°C

Harrison, P.M., and Arosio, P., The ferritins: molecular properties, iron storage function and cellular regulation. Biochim. Biophys. Acta 1275, 161-203, (1996)

Yang, X., and Chasteen, N.D., Ferroxidase activity of ferritin: effects of pH, buffer and Fe(II) and Fe(III) concentrations on Fe(II) autoxidation and ferroxidation. Biochem. J. 338, 615-618, (1999)

Double, K.L., et al., In vitro studies of ferritin iron release and neurotoxicity. J. Neurochem. 70, 2492-2499, (1998)

Yoshida, T., et al., Activated microglia cause iron-dependent lipid peroxidation in the presence of ferritin. Neuroreport 9, 1929-1933, (1998)

Picard, V., et al., Role of ferritin in the control of the labile iron pool in murine erythroleukemia cells. J. Biol. Chem. 273, 15382-15386, (1998)

B

3