F6886
Sigma

Forskolin

from Coleus forskohlii, ≥98% (HPLC), powder

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Synonym

7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one

Coleonol

Colforsin

Molecular Formula

C₂₂H₃₄O₇

Molecular Weight

410.50

CAS Number

66575-29-9

Beilstein Registry Number

1692716

MDL number

MFCD00082317

PubChem Substance ID

24278035

EG/EC Number

266-410-9

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Descriptions

Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.¹ Forskolin effects calcium currents and inhibits MAP kinase.

Properties

biological source

from Coleus forskohlii

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: 5 mg/mL stable at least 6 months at room temperature

ethanol: soluble

Gene Information

human ... OPRK1(4986), SLC2A10(81031), TNF(7124)

References

Cited Reference

1. de Souza, N.J., Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties. Med. Res. Rev. 3, 201, (1983)

Reference

Huang, R.D., Inhibition of forskolin-activated adenylate cyclase by ethanol and other solvents. J. Cyclic Nucleotide Res. 8, 385, (1982)

Galli, C., Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action. J. Neurosci. 15, 1172, (1995)

Seamon, K. B., Daly, J. W., Forskolin: its biological and chemical properties. Adv. Cyclic Nucleotide Protein Phosphorylation Res. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1, (1986)

Li, X., Inhibition of MAP kinase by prostaglandin E2 and forskolin in rat renal mesangial cells. Am. J. Physiol. 269, 986, (1995)

Siddhanti, S.R., Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts. Endocrinology 136, 4834, (1995)

Merck

Merck 13,2500

Beilstein

Beil. 18,V,5,55

Safety

Hazard Codes

Risk Statements

Safety Statements

22-36/37

WGK Germany

RTECS

QL6150000