F6926
Sigma

Fibroblast Growth Factor-8b from mouse

>97% (SDS-PAGE), recombinant, expressed in Escherichia coli, lyophilized powder

Synonym

FGF-8b

MDL number

MFCD01323276

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Descriptions

Analysis Note

The biological activity is measured by its ability to stimulate ³H-thymidine incorporation in confluent quiescent NR6R-3T3 fibroblasts.

Physical form

Lyophilized from a 0.2 μm filtered solution in 20% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Biochem/physiol Actions

FGF-8b plays a role in ectodermal differentiation in the post-gastrulation embryo, including outgrowth and patterning of the face, limbs, and central nervous system. FGF-8b activates the "c" splice form of FGFR-2, FGFR-3, and FGFR-4.

Properties

recombinant

expressed in Escherichia coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt 23.6 kDa

predicted mol wt 22 kDa

total impurities

Endotoxin, tested

Gene Information

mouse ... Fgf8(14179)

storage temp.

−20°C

References

Reference

MacArthur, C.A. Development 121, 3603, (1995)

Crossley, P.H. Cell 84, 127, (1996)

Gemel, J., et al. Genomics 35, 253, (1996)

Safety

WGK Germany

Related Categories

... Hematopoietic Stem Cell Expansion/Differentiation > Cytokine/Growth Factor

... Neural Stem Cell Differentiation > Embryonic Stem Cell Differentiation into Neuron

... Fibroblast Growth Factors (FGF) > FGF

... Receptor Tyrosine Kinases > Fibroblast Growth Factor Receptor (FGFR)

... Cytokines/Growth Factors/Chemokines > Growth Factors

F6926 - Datasheet (31kb)

MSDS

Certificate of Analysis

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F6926 (Sigma)