Fumitremorgin C 

Store desiccated at 2-8 °C. Under these conditions, the product is stable for 2 years. A solution in DMSO is stable for 2 months at 2-8 °C.

Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds. In mammalian cells, FTC is tremorgenic and causes cell cycle arrest. Fumitremorgin C has been shown to reverse resistance to doxorubicin, mitoxantrane, and topotecan in non-Pgp (P-glyco­protein), non-MRP (multidrug resistance protein) multidrug-resistance (MDR) cells. This reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is a specific, selective, and potent inhibitor at micromolar concentrations of the breast cancer resistant protein (BCRP/ABCG2), an ABC transporter associated with chemotherapy resistance. FTC, in combination with mitoxantrone, can be used for the detection of ABCG2 functional activity in several cell lines.

from Neosartorya fischeri

>98% (HPLC and TLC)

solid

acetonitrile: 5 mg/mL, soluble

methanol: 5 mg/mL, soluble

DMSO: soluble

chloroform: soluble

wet ice

2-8°C

Van Loevezijn, A., et al., Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines. Bioorg. Med. Chem. Lett. 11, 29-32, (2001) abstract

Rabindran, S.K., et al., Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 60, 47-50, (2000) abstract

Cui, C.B., et al., Novel mammalian cell cycle inhibitors, tryprostatins A, B, and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation, and biological properties. J. Antibiot. 49, 527-533, (1996) abstract

Minderman, H., et al., Flow cytometric analysis of breast cancer resistance protein expression and function. Cytometry 48, 59-65, (2002) abstract

Rabindran, S.K., et al., Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res. 58, 5850-5858, (1998) abstract

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