Analysis Note
Bioactivity is measured by the ability to stimulate the proliferation of a Flt-3 transfected pro-B cell line.
Biochem/physiol Actions
Flt-3 (fms-like tyrosine kinase)/Flk-2 (fetal liver kinase) ligand is a member of a small family of growth factors that stimulate the proliferation of hematopoietic cells by binding to and activating distinct tyrosine kinase receptors.1
Quality
Heterogenous glycosylation causes recombinant mouse Flt-3 ligand to migrate as multiple bands from 18-32 kDa.
Physical form
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.25 mg bovine serum albumin.
General description
Mouse and human Flt-3 ligand share approximately 72% homology and both demonstrate cross-species activity.
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