G137
Sigma

(2S,4R)-4-Methylglutamic acid

solid

zoom

1 of 1

Synonym

SYM-2081

Molecular Formula

C₆H₁₁NO₄

Molecular Weight

161.16

CAS Number

31137-74-3

MDL number

MFCD00937765

PubChem Substance ID

24895059

Expand/Collapse All

Descriptions

Biochem/physiol Actions

Selective and high affinity kainate receptor antagonist.

Properties

form

solid

optical activity

[α]23/D +23.2°, c = 0.73 in 6 M HCl(lit.)

color

white

solubility

H₂O: >10 mg/mL

Gene Information

human ... GRIK1(2897), GRIK2(2898), SLC1A1(6505), SLC1A2(6506)

rat ... Gria1(50592), Grik1(29559), Grin2a(24409), Slc1a2(29482)

References

Reference

Ta, L.E., et al., SYM-2081 a kainate receptor antagonist reduces allodynia and hyperalgesia in a freeze injury model of neuropathic pain. Brain Res. 858, 106-120, (2000) abstract

Jones, K.A., et al., Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 36, 853-863, (1997) abstract

Zhou, L.M., et al., (2S,4R)-4-methylglutamic acid (SYM 2081): a selective high-affinity ligand for kainate receptors. J. Pharmacol. Exp. Ther. 280, 422-427, (1997) abstract

Toms, N.J., et al., A novel kainate receptor ligand [³H]-(2S,4R)-4-methylglutamate: pharmacological characterization in rabbit brain membranes. Neuropharmacology 36, 1483-1438, (1997)

Safety

WGK Germany