G3670
Sigma

Galectin-8 from rat

recombinant, expressed in Escherichia coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution

Synonym

Gal-8

Po66 carbohydrate-binding protein

Prostate carcinoma tumor antigen 1

MDL number

MFCD07785205

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Descriptions

Analysis Note

The biological activity is measured by its ability to agglutinate human red cells.

Physical form

Solution containing 20 mM Tris, pH 7.4, 1 mM DTT, 1 mM EDTA, and 30% glycerol.

Biochem/physiol Actions

Galectin-8 is a family member of animal lectins which selectively binds β-galactoside residues. It is a widely expressed 34 kDa protein, which is secreted by many cell types. Galectin-8 is made of two homologous regions, each having a single carbohydrate recognition domain (CRD), linked by a short peptide. Galectin-8 acts as a physiological modulator of cell adhesion and cellular growth, and may be involved in neoplastic transformation.

Properties

recombinant

expressed in Escherichia coli

assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

Gene Information

rat ... Lgals8(116641)

shipped in

dry ice

storage temp.

−20°C

References

Reference

Levy, Y., et al., Galectin 8 functions as a matricellular modulator of cell adhesion. J. Biol. Chem. 17, 31285-31295, (2001)

Hadari, Y.R., et al., Galectin 8 binding to integrins inhibits cell adhesion and induces apoptosis. J. Cell Sci. 113, 2385-2397, (2000) abstract

Camby, I., et al., Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration. Brain Pathol. 11, 12-26, (2001) abstract

Safety

WGK Germany