G3767
Sigma

Trisialoganglioside-GT_1b from bovine brain

lyophilized powder, ≥96% (TLC)

Synonym

Ganglioside GT_1b

Amino Acid Sequence

Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal-NeuAc

CAS Number

59247-13-1

MDL number

MFCD00081622

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Descriptions

Analysis Note

Homogeneous aqueous preparations can be obtained by suspending the compound in water, buffer or cell culture medium and sonicating briefly to facilitate the micelle formation.

Biochem/physiol Actions

Ganglioside marker for metastatic brain tumors. Modulates cellular differentiation; prevents glutamate neurotoxicity; inhibits mitogenesis stimulated by lectins such as ConA. Converted to GD_1b by bacterial and mammalian sialidases.

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Properties

assay

≥96% (TLC)

form

lyophilized powder

solubility

DMSO: soluble

ethanol: soluble

storage temp.

−20°C

References

Reference

Fishman, Gangliosides as cell surface receptors and transducers of biological signals. New Trends in Ganglioside Research, (1988) 14, 219

Favaron, M., et al., Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc. Natl. Acad. Sci. USA 85, 7351-7355, (1988) abstract

Hamasaki, H., et al., G_T1b in human metastatic brain tumors: G_T1b as a brain metastasis-associated ganglioside. Biochim. Biophys. Acta 1437, 93, (1999) abstract

Tettamanti, Towards the understanding of the physiological role of gangliosides. New Trends in Ganglioside Research, (1988) 14, 625

Safety

WGK Germany