G7641
Sigma

Monosialoganglioside G_M1 from bovine brain

≥95%, lyophilized powder

Synonym

Ganglioside G_M1, monosialo

Amino Acid Sequence

Cer-Glc-Gal(NeuAc)-GalNAc-Gal

CAS Number

37758-47-7

MDL number

MFCD00466936

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Descriptions

Application

Specific receptors for cholera toxin that accumulate in the brain in late infantile lipidosis.

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Properties

assay

≥95%

form

lyophilized powder

storage temp.

−20°C

References

Reference

Minke, W.E., et al., Structure-based exploration of the ganglioside G_M1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists. Biochemistry 38, 5684, (1999)

Lanne, B., et al., Binding of cholera toxin B-subunits to derivatives of the natural ganglioside receptor G_M1. J. Biochem. Tokyo 126, 226, (1999)

Kuziemko, G.M., Cholera toxin binding affinity and specificity for gangliosides determined by surface plasmon resonance. Biochemistry 35, 6375, (1996)

Hahn, C.N., et al., Generalized CNS disease and massive G_M1-ganglioside accumulation in mice defective in lysosomal acid β-galactosidase. Hum. Mol. Genet. 6, 205, (1997)

Safety

WGK Germany

10-21

Related Categories

... Lipids in Cell Signaling > Gangliosides

... Acidic glycosphingolipids > Gangliosides

... Glycosphingolipids > Gangliosides

G7641 - Product Information Sheet (58kb)

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information

Monosialoganglioside GM1 from bovine brain

≥95%, lyophilized powder

Monosialoganglioside G_M1 from bovine brain