G8022
Sigma

Gastrin Releasing Peptide human

≥97% (HPLC)

Synonym

GRP

Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH₂

Molecular Formula

C₁₃₀H₂₀₄N₃₈O₃₁S₂

Molecular Weight

2859.38

CAS Number

93755-85-2

MDL number

MFCD00133362

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Descriptions

Linkage

Mammalian equivalent of bombesin that is found in the central nervous system and gastrointestinal tract. It inhibits food intake. It is produced by and is mitogenic for several tumor cell lines.

Properties

assay

≥97% (HPLC)

composition

Peptide content, ~70%

storage temp.

−20°C

References

Reference

Sharif, T.R., et al., Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway. Mol. Cell. Endocrinol. 130, 119-130, (1997)

Jensen, J.A., et al., The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer. Peptides 22, 689-699, (2001)

Konturek, S.J., et al., Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion. Eur. J. Pharmacol. 481, 1-14, (2003)

Carroll, R.E., et al., Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer. Cell. Growth Differ. 11, 385-393, (2000)

Merali, Z., et al., Role of bombesin-related peptides in the control of food intake. Neuropeptides 33, 376-386, (1999)

Safety

WGK Germany