G8165
Sigma

Galanin (1-13)-Neuropeptide Y (25-36) Amide

≥90%

Synonym

m32

Amino Acid Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH₂

Molecular Formula

C₁₃₆H₂₀₉N₄₁O₃₄

Molecular Weight

2962.37

MDL number

MFCD00798702

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Descriptions

Biochem/physiol Actions

This chimeric peptide is a high affinity galanin receptor antagonist (IC₅₀=0.1 nM in rat hypothalamus membranes and Kd=0.01 nm in rat spinal cord membranes). This peptide is also recognized by neuropeptide Y receptors (IC₅₀=0.25 μM in rat cerebral cortex membranes) and is a Y₂ agonist in rat vas deferens.

Properties

assay

≥90%

Gene Information

human ... GAL(51083), NPY(4852)

storage temp.

−20°C

References

Reference

Arvidsson, K., et al., Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors. Biochemistry 32, 7787-7798, (1993) abstract

Kahl, U., et al., Functional effects and ligand binding of chimeric galanin-neuropeptide Y (NPY) peptides on NPY and galanin receptor types. Br. J. Pharmacol. 111, 1129-1134, (1994) abstract

Xu, X.-J., et al., New high affinity peptide antagonists to the spinal galanin receptor. Pharmacology 116, 2076-2080, (1995)

Safety

WGK Germany