G8272
Sigma

Galanin rat

≥97% (HPLC), powder

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Amino Acid Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-His-Gly-Leu-Thr-NH₂

Molecular Formula

C₁₄₁H₂₁₁N₄₃O₄₁

Molecular Weight

3164.45

CAS Number

114547-31-8

MDL number

MFCD00133354

PubChem Substance ID

24895336

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Descriptions

Biochem/physiol Actions

Co-localized with acetylcholine and inhibits its release; inhibits the release of glutamic acid, decreases excitability of spinal neurons; blocks voltage-activated Ca²⁺ channels; linked to behavioral and cognitive deficits in Alzheimer's disease.

Properties

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ≥65%

Gene Information

rat ... Gal(29141)

storage temp.

−20°C

References

Reference

Todd, J.F., et al., Galanin is a paracrine inhibitor of gonadotroph function in the female rat. Endocrinology 39, 4222-4229, (1998)

Korolkiewicz, R., Pharmacological characterization of the contractile effects of galanin (1-29)-NH2, galantide and galanin (1-14)-(alpha-aminobutyric acid)scyliorhinin-I in the rat gastric fundus. Fundam. Clin. Pharmacol. 11, 576, (1997) abstract

Wang, S., et al., The GalR2 galanin receptor mediates galanin-induced jejunal contraction but not feeding behavior in the rat: differentiation of central and peripheral effects of receptor subtype activation. FEBS Lett. 434, 277-82, (1998) abstract

Safety

WGK Germany

Related Categories

... Neuropeptides > Galanins

Galanin Receptors (190 kb)

MSDS

Certificate of Analysis

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G8272 (Sigma)