G9145
Sigma

[Leu¹⁵]-Gastrin I human

≥97% (HPLC)

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Synonym

[15-Leucine]-Gastrin I, human heptadecapeptide

[Leu¹⁵]-Gastrin I, human

[Leu¹⁵]-HG-17

[Leucine¹⁵]-Gastrin I heptadecapeptide

[Leucine¹⁵]-Little gastrin I

LHG-17

[18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human

Amino Acid Sequence

pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH₂

Molecular Formula

C₉₈H₁₂₆N₂₀O₃₁

Molecular Weight

2080.16

CAS Number

39024-57-2

Beilstein Registry Number

5227423

MDL number

MFCD00076502

PubChem Substance ID

24895364

EG/EC Number

254-250-2

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Descriptions

Biochem/physiol Actions

Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu¹⁵ replaces Met¹⁵, that is readily oxidized resulting in loss of biological activity.

Properties

assay

≥97% (HPLC)

Gene Information

human ... GAST(2520)

storage temp.

−20°C

References

Reference

Zhao, C.M., et al., ECL cells of the rat stomach: development of lipofuscin in response to sustained gastrin stimulation. Cell Tissue Res. 291, 315-323, (1998) abstract

Reubi, J.C., et al., Cholecystokinin CCK-_A and CCK-_B/gastrin receptors in human tumors. Cancer Res. 57, 1377, (1997) abstract

Chen, D., et al., Gastrin does not stimulate growth of the rat pancreas. Scand. J. Gastroenterol. 31, 404-410, (1996) abstract

Safety

WGK Germany