Antigen Background
The GABABR2 was shown to be essential for trafficking and G-protein binding, while the GABAB R1 subunit was demonstrated to be important for agonist and antagonist binding. GABABR2 is highly expressed in brain especially at the cerebral cortex, thalamus, hippocampus, and spinal cord and to a lesser extent in testis.
Immunogen
peptide CKDPIEDINSPEHIQRRLSL corresponding to residues 875-894 of human GABABR2.
Reconstitution
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.