General description
This reference provides coverage of current screening techniques, modern technologies, and high-capacity instrumentation for development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It describes the construction and compilation of chemical compound databases and clinical trials. It contains applications and examples of strategies in cell-based and cell-free screens, as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies It covers identification of transcriptional factors for drug targeting; affinity-based approaches to screening; the role of proteomics and bioinformatics in target identification; laboratory automation and assay miniaturization in ultrahigh-throughput screening.
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