H128
Sigma

(R)(−)-α-Methylhistamine dihydrochloride

solid, ≥98% (HPLC)

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Synonym

R(−)-α-Methyl-1H-imidazole-4-ethanamine dihydrochloride

Molecular Formula

C₆H₁₁N₃ · 2HCl

Molecular Weight

198.09

CAS Number

75614-89-0

MDL number

MFCD00083176

PubChem Substance ID

24277778

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Descriptions

Biochem/physiol Actions

Potent, selective H₃ histamine receptor agonist which crosses the blood-brain barrier; inhibits histamine synthesis and release.

Properties

assay

≥98% (HPLC)

form

solid

optical activity

[α]22/D −4°, c = 0.8 in H₂O(lit.)

storage condition

desiccated

color

white to off-white

solubility

H₂O: soluble

Gene Information

human ... HRH3(11255)

References

Reference

Oishi, et al., Effects of the histamine H₃-agonist (R)-α-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain. J. Neurochem. 52, 1388, (1989) abstract

Arrang, J. M., et al., Highly potent and selective ligands for histamine H₃-receptors. Nature 327, 117, (1987) abstract

Gerhard, et al., Structure-activity relations of histamine analogs. XX. Absolute configuration and histamine-like activity of enantiomeric α-methyl histamines. Arch. Pharm. Res. 313, 709, (1980)

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Related Categories

... Histaminergics > Agonists

MSDS

Certificate of Analysis

Certificate of Origin

More Information