H1384
Sigma

Hypotaurine

≥98% (TLC)

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Synonym

2-Aminoethanesulfinic acid

Molecular Formula

C₂H₇NO₂S

Molecular Weight

109.15

CAS Number

300-84-5

MDL number

MFCD00038197

PubChem Substance ID

24278460

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Descriptions

Biochem/physiol Actions

Antioxidant that binds hydroxyl radicals. Endogenous inhibitory neuromodulator that is blocked by strychnine and picrotoxin. Inhibits the Na²⁺-dependent transport of GABA and β-alanine. It is a degradation product of cysteine and a precursor of taurine.

Packaging

10 mg in autosmp vl

Properties

assay

≥98% (TLC)

color

white

solubility

H₂O: 100 mg/mL

References

Reference

Green, T.R., et al., Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim. Biophys. Acta 1073, 91-97, (1991) abstract

Ramanathan, V. K., Na⁺ -dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. Biochim. Biophys. Acta 1330, 94, (1997) abstract

Brand, A., et al., Metabolism of cysteine in astroglial cells: synthesis of hypotaurine and taurine. J. Neurochem. 71, 827-832, (1998) abstract

Saransaari, P., and Oja, S.S., Uptake and release of β-alanine in cerebellar granule cells in primary culture: regulation of release by glutamatergic and GABAergic receptors. Neuroscience 53, 475-481, (1993) abstract

Okamoto, K., and Sakai, Y., Inhibitory actions of taurocyamine, hypotaurine, homotaurine, taurine and GABA on spike discharges of Purkinje cells. Brain Res. 206, 371-386, (1981) abstract

Tadolini, B., et al., Effects of taurine and hypotaurine on lipid peroxidation. Biochem. Biophys. Res. Commun. 213, 820-826, (1995) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany