H1512
Sigma

Haloperidol

powder

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1 of 1

Synonym

4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone

4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone

4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone

Molecular Formula

C₂₁H₂₃ClFNO₂

Molecular Weight

375.86

CAS Number

52-86-8

MDL number

MFCD00051423

PubChem Substance ID

24277917

EG/EC Number

200-155-6

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Descriptions

Biochem/physiol Actions

Butyrophenone antipsychotic; D₂, D₃, and D₄ dopamine receptor antagonist.

Properties

form

powder

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL

0.1 M HCl: 3 mg/mL

DMSO: soluble

H₂O: insoluble

ethanol: soluble

Gene Information

human ... ABCB1(5243), ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), EBP(10682), HRH1(3269), HTR2A(3356), HTR2C(3358), HTR7(3363), KCNH1(3756), KCNH2(3757), PRNP(5621)

rat ... Adra1a(29412), Adra2a(25083), Chrm1(25229), Chrm2(81645), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2c(25187), Oprs1(29336), Slc6a3(24898), Slc6a4(25553)

References

Reference

Nakahara, T., Effects of atypical antipsychotic drugs vs. haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine treated rates. Brain Res. Mol. Brain Res. 73, 193, (1999) abstract

Zhang, W., et al., Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: a possible model for the screening of atypical antipsychotics. Neuroreport 10, 2533, (1999) abstract

Kim, S.K., et al., Expression of neuropeptide Y by glutamatergic stimulation in rat C6 glioma cells. Neurochem. Int. 36, 19, (2000) abstract

Merck

Merck 13,4613

Safety

Hazard Codes

Risk Statements

60-61-25-36/37/38-43

Safety Statements

53-26-36/37/39-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany